Therapies targeting Cancer Stem Cells

Traditional therapies against cancer, chemo- and radiation therapy have multiple limitations that result in treatment failure and cancer repetition. These limitations are associated with general and native toxicity, whereas treatment failure and cancer relapse are thanks to drug resistance and self-renewal, properties of a little population of growth cells known as cancer stem cells (CSCs). These cells are concerned in cancer initiation, maintenance, metastasis and repeat. Therefore, in order to develop economical treatments that may induce a long clinical response preventing growth relapse it's necessary to develop medication which will specifically target and eliminate CSCs. Recent identification of surface markers and understanding of molecular feature related to CSC makeup helped with the look of effective treatments. during this review we have a tendency to discuss targeting surface biomarkers, communication pathways that regulate CSCs self-renewal and differentiation, drug-efflux pumps concerned in programmed cell death resistance, micro environmental signals that sustain CSCs growth, manipulation of miRNA expression, and induction of CSCs programmed cell death and differentiation, with specific aim to hamper CSCs regeneration and cancer relapse. a number of these agents are underneath analysis in diagnosis and clinical studies, most of them for victimization together with ancient therapies. The combined therapy victimization standard antitumor medication with CSCs-targeting agents might provide a promising strategy for management and eradication of various kinds of cancers.


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